Furfural → 7-Bromo-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Reaktionsgleichung

[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[CH:24](=O)[C:25]1[O:29][CH:28]=[CH:27][CH:26]=1>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:24]([C:25]3[O:29][CH:28]=[CH:27][CH:26]=3)[N:9]=[C:4]2[CH:3]=1

Komponenten

Edukt 3

HCID 7362Furfural

HCID 114353934-Bromo-2,6-diaminopyridine

HCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Produkt 1

HCID 111967207-Bromo-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Versuchsvorschrift

The title compound, MS m/e (%): 281 (M++2, 100), was prepared in accordance with the (general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and furfural. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Quellen und Nachweise

ORD-Eintrag: ord-dfa623cc28a3463fada715a8f4f70dbb
Quelldatensatz: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06355653B1

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