Hydrochloric Acid → 2-Allyl-3,6-difluorophenol

HRID 277176Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 277176
C([O:4][C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[F:12])C=C.Cl.CN(C)[C:16]1[CH:21]=CC=C[CH:17]=1>>[CH2:21]([C:10]1[C:9]([F:11])=[CH:8][CH:7]=[C:6]([F:12])[C:5]=1[OH:4])[CH:16]=[CH2:17]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 949N,N-DimethylanilineHCID 107496562,5-Difluorophenol allyl ether

Produkt 1

HCID 108448632-Allyl-3,6-difluorophenol

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

13 g 2,5-difluorophenol allyl ether was dissolved in 90 ml N,N-dimethylaniline and stirred at 170° C. for 5 hours in a nitrogen stream. The reaction solution was poured into 10% aqueous hydrogen chloride solution and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and then evaporated The resulting residue was subjected to silica gel chromatography (developing solvent: 7% ethyl acetate/n-hexane) to give 7.8 g of 2-allyl-3,6-difluorophenol as a colorless oil.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated The resulting residue

Quellen und Nachweise

ORD-Eintrag
ord-5721013ff3da4700b2908d8de6d458df
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06355669B1

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