Hydrochloric Acid → HCID 131723149, Verbindung

HRID 278265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 278265
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, Verbindung

Produkt 1

HCID 131723149HCID 131723149, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1398036eb6344e37bc434aa85c432c23
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06358979B1

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