Hydroxycaprylic Acid → Methyl 2-hydroxyoctanoate

HRID 278462

Reaktionsgleichung

Reaktionsgleichung von HRID 278462
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([OH:5])=[O:4].[CH3:12]O.Cl>>[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH3:12])=[O:4]

Komponenten

3

Edukt 2

HCID 94180Hydroxycaprylic AcidHCID 21893726Hydrochloride methanol

Produkt 1

HCID 10487462Methyl 2-hydroxyoctanoate

Versuchsvorschrift

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

Aufarbeitung

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customThe residue was partitioned between ethyl acetate and water
  3. washThe organic layer was washed with aqueous NaHCO3 solution
  4. dry with materialdried over sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-40c1c3396bad46d08b4711877faefc2a
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06359145B1

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