Sodium Hydroxide → 5-(Pyridin-4-yl)thiophene-2-carboxylic acid

HRID 278555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 278555
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:11][C:10]([C:12]([O:14]C)=[O:13])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[S:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 21928559Methyl 5-(pyridin-4-yl)thiophene-2-carboxylate

Produkt 1

HCID 219285765-(Pyridin-4-yl)thiophene-2-carboxylic acidAusbeute 94,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of the obtained methyl 5-(4-pyridyl)-2-thiophenecarboxylate (410 mg) in ethanol (20 ml) was added 1 N sodium hydroxide solution (4 ml) and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated, and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound (363 mg).

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (4 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b3bd37bc43a0402180e8c64f02ce3d2b
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06359134B1

Notizen zur Reaktion

Wird geladen…