Sodium Hydroxide → 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

HRID 278562

Reaktionsgleichung

Reaktionsgleichung von HRID 278562
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([O:14]CC)=[O:13])[N:11]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([OH:14])=[O:13])[N:11]=2)=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 595483Ethyl 2-(pyridin-4-YL)thiazole-4-carboxylate

Produkt 1

HCID 7160912-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acidAusbeute 95,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of the obtained ethyl 2-(4-pyridyl)-4-thiazolecarboxylate (1.5 g) in ethanol (10 ml) was added 1 N sodium hydroxide solution (10 ml), and the solution was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in water, to which was added 1 N hydrochloric acid (10 ml). The precipitate was filtered, washed with water and dried to give the title compound (1.264 g).

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (10 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e1ede9ccf4ad448984aee4eacd500246
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06359134B1

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