HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Edukt | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Edukt | 1-Tritylpiperidine-4-carboxylic acid | HCID 20520182 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine | HCID 22628088 | — |
Reaktionsschritte
To a mixture of 1-tritylpiperidine-4-carboxylic acid (7.0 g), O,N-dimethylhydroxylamine hydrochloride (2.0 g) and triethylamine (2.9 ml) in dichloromethane (70 ml) was added WSC (3.97 g), and the mixture was stirred at room temperature for 1 hour and concentrated. To the residue was added ethyl acetate, and the mixture was washed with water, dried (MgSO4) and concentrated. The resulting crystals (6.3 g) were washed with isopropylether.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06359134B1 |
| Quelldatensatz | uspto-grants-2002_03 |
| ORD ID | ord-13e3f414752049a18edaff60a4782d74 |
| Quellennotiz | uspto-grants-2002_03 |