Methyl iodide → 1-Isopropyl-3-methoxy-benzene

HRID 278792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 278792
[CH:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2].[C:11]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 120593-Isopropylphenol

Produkt 1

HCID 109316061-Isopropyl-3-methoxy-benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 3-isopropyl-phenol (5.00 g, 36.2 mmols) in 50 mL of acetone was added K2CO3(7.50 g, 54.3 mmols) and iodomethane (10.3 g, 72.5 mmols). The resulting solution was heated to 50° C. and stirred for 18 hours, cooled to room temperature, and concentrated under reduced pressure. The residual oil was dissolved in Et2O and washed with H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The crude methyl ether was used without further purification.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residual oil was dissolved in Et2O
  4. washwashed with H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl
  5. dry with materialbefore being dried (MgSO4)
  6. concentrationconcentrated under reduced pressure
  7. customThe crude methyl ether was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d938e27d9ca04d1eba7cdcc59e746382
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06359135B1

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