Nitric Acid → 3-Chloro-6-(3,5-dimethyl-4-nitro-1-pyrazolyl)-pyridazine

Beteiligte Stoffe

Reaktionsschritte

To a mixture of 230 ml of concentrated sulphuric acid and 230 ml of 100% nitric acid, 26 g of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine are added portionwise, under stirring at a temperature between 0° C. and 5° C., then the mixture is stirred at room temperature for 2 hours, poured into 1 liter of water and set aside overnight in the refrigerator. The separated crystals are filtered, washed with water and dried. Yield: 26.7 g (84.5%); m.p. 164°-167° C.

Herkunft & Nachweise