Hydrochloric Acid → 3,5-Dichloro-2-isothiocyanatopyridine

HRID 27901

Reaktionsgleichung

Reaktionsgleichung von HRID 27901
[Cl:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.[N-]=[C:12]=[S:13]>>[Cl:1][C:2]1[C:3]([N:9]=[C:12]=[S:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 778863,5-Dichloro-3-pyridylamineHCID 178418790HCID 178418790, Verbindung

Produkt 1

HCID 233404453,5-Dichloro-2-isothiocyanatopyridine

Versuchsvorschrift

3,5-Dichloro-2-amino pyridine (8.15, 0.05 mol) was treated with thiophosgenes (10% soln. in toluene, 55 ml). The mixture was refluxed until clear solution was obtained and no further hydrochloric acid gas was being evolved. The mixture was cooled, and the solid which crystallised was removed by filtration. The mother liquors, after evaporation and crystallisation of the residual oil, yielded 5.5 g. (55%) of the required isothiocyanate as pale yellow needles m. pt. 45°-6°.

Aufarbeitung

  1. temperatureThe mixture was refluxed until clear solution
  2. customwas obtained
  3. temperatureThe mixture was cooled
  4. customthe solid which crystallised
  5. customwas removed by filtration
  6. customThe mother liquors, after evaporation and crystallisation of the residual oil
  7. customyielded 5.5 g

Quellen und Nachweise

ORD-Eintrag
ord-dffacfefda164193be659bca22101673
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04224331

Verknüpfte Notizen

Wird geladen…