Triethylamine → 2-Phenylglycine

HRID 279086

Reaktionsgleichung

Reaktionsgleichung von HRID 279086
C(N(CC)CC)C.C([NH:11][CH:12]([CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:13]([OH:15])=[O:14])(=O)C>C(OCC)(=O)C>[NH2:11][CH:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13]([OH:15])=[O:14]

Komponenten

4

Edukt 2

HCID 8471TriethylamineHCID 97942122-Acetamido-2-cyclohexylacetic acid

Produkt 1

HCID 38662-Phenylglycine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Triethylamine (8.39 ml) was added to a suspension of DL-N-acetyl-2-cyclohexylglycine (10.00 g) obtained from α-aminophenylacetic acid according to a known method [Collect. Czeck. Chem. Commun., 31: 4563 (1996)] in ethyl acetate (50 ml). Ethyl chlorocarbonate (5.28 ml) was dropwise added to the mixture under ice-cooling. The mixture was stirred under ice-cooling for one hour, added with ethyl acetate (150 ml), and washed successively with water and saturated brine. The ethyl acetate solution was concentrated under reduced pressure to give 9.86 g of the title compound as an oil.

Quellen und Nachweise

ORD-Eintrag
ord-44d8343431cb473fad57ca7ce53f5d85
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06362209B1

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