HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 3-Phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| Edukt | 2-(1-Benzothiophen-2-yl)-3-methylbutanoic acid | HCID 23340392 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Lösungsmittel | tetrahydrofuran HMPA | HCID 86583969 | — |
| Produkt | 3-Phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate | HCID 13146350 | — |
Reaktionsschritte
A mixture of 2-(2-benzothienyl)-3-methylbutanoic acid (1 g, 4.3 mmol), 3-phenoxybenzyl bromide (1.1 g, 4.3 mmol) and K2CO3 (8.6 mmol) in 25 ml of THF/HMPA (1:1) is stirred overnight. The reaction is worked up by diluting with ether, washing with water, drying over Na2SO4, and solvent removed to yield 3-phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate which can be further purified by preparing thin layer chromatography eluting with 5 percent ether/hexane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04224330 |
| Quelldatensatz | uspto-grants-1980_09 |
| ORD ID | ord-d94f0e1a4a804ee5b7e4f30bc6605920 |
| Quellennotiz | uspto-grants-1980_09 |