HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| Edukt | 2-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid | HCID 54204673 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate | HCID 54477689 | — |
Reaktionsschritte
A mixture of 20 ml DMF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.51 g) and 3-phenoxybenzyl bromide (0.44 g) is stirred, under nitrogen, for about 15 hours. The mixture is then taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ether/hexane to give 3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04224330 |
| Quelldatensatz | uspto-grants-1980_09 |
| ORD ID | ord-afd7ba97cc11477984f0728908ef7c09 |
| Quellennotiz | uspto-grants-1980_09 |