Trichloroacetic Acid → 2,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

HRID 279692

Reaktionsgleichung

Reaktionsgleichung von HRID 279692
[F:1][C:2]1[C:7]([C:8](=[O:20])[C:9]2[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=2[F:19])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].[Cl:25][C:26]([Cl:31])([Cl:30])C(O)=O.FF.C([O-])(=O)C=C>CO.CN(C)P(N(C)C)(N(C)C)=O>[Cl:25][C:26]([Cl:31])([Cl:30])[C:8]([C:9]1[C:10]([F:19])=[C:11]([F:18])[C:12]([F:17])=[C:13]([F:16])[C:14]=1[F:15])([C:7]1[C:2]([F:1])=[C:3]([F:24])[C:4]([F:23])=[C:5]([F:22])[C:6]=1[F:21])[OH:20]

Komponenten

7

Edukt 4

HCID 6421Trichloroacetic AcidHCID 24524FluorineHCID 25188AcrylateHCID 70068Decafluorobenzophenone

Produkt 1

HCID 226252562,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittel2×HCID 12679HexamethylphosphoramideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 4.9 g of decafluorobenzophenone and 2.7 g of trichloroacetic acid was added to 15 mL of hexamethylphosphoramide. The stirred reaction mixture was maintained at about 0° C. for about 2 hours and then allowed to warm to room temperature and continue stirring at ambient temperature for the next 15 hours. The reaction mixture was characterized by GC and fluorine NMR to show a conversion of approximately 20% to the desired carbinol. This carbinol can be converted to the corresponding acrylate by methods previously described (cf. Example 24).

Aufarbeitung

  1. customThe stirred reaction mixture
  2. temperatureto warm to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-a5294303fdcc4562a1bcd0a97cbe79d7
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06362379B1

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