Benzene → HCID 13505928, Verbindung

HRID 279775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 279775
C([C:3](CC)(Cl)[C:4]([N:6]([CH:18]([C:22]([O-:24])=[O:23])[C:19]([O-:21])=[O:20])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[O:16][CH3:17])=[O:5])C.[CH2:28](N(CC)CC)[CH3:29].[CH:35]1C=CC=C[CH:36]=1>>[CH2:28]([O:21][C:19]([C:18]1([C:22]([O:24][CH2:35][CH3:36])=[O:23])[CH2:3][C:4](=[O:5])[N:6]1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[O:16][CH3:17])=[O:20])[CH3:29]

Komponenten

4

Edukt 3

HCID 241BenzeneHCID 8471TriethylamineHCID 131714654HCID 131714654, Verbindung

Produkt 1

HCID 13505928HCID 13505928, VerbindungAusbeute 89 %

Versuchsvorschrift

A mixture of 35 g (0.087 mole) of diethyl-[N-(2,4-dimethoxy-benzyl)-N-(chloro-acetyl)-amino-malonate], 15.9 ml (11.4 g, 0.113 mole) of triethylamine and 200 ml of anhydrous benzene is heated to boiling for 8 hours. The mixture is extracted successively with 100 ml of water, 100 ml of diluted hydrochloric acid and 100 ml of water, the benzene phase is dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated. Thus 28,4 g of diethyl-[1-(2,4-dimethoxy-benzyl)-4-oxo-2,2-azetidine-dicarboxylate] are obtained, yield: 89%. B.p.: 175°-180° C./0.1 Hgmm.

Aufarbeitung

  1. temperatureis heated
  2. extractionThe mixture is extracted successively with 100 ml of water, 100 ml of diluted hydrochloric acid and 100 ml of water
  3. dry with materialthe benzene phase is dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-1bb1e10fd79644a2baee655155b14b0b
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04587049

Notizen zur Reaktion

Wird geladen…