p-Toluenesulfonic acid → 1-Ethoxy-1-(imidazol-4-yl)methoxy ethane
Reaktionsgleichung
Cl.[OH:2][CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1.[CH:9]([O:11][CH2:12][CH3:13])=[CH2:10].C1(C)C=CC(S(O)(=O)=O)=CC=1>CN(C)C=O>[CH2:9]([O:11][CH:12]([O:2][CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)[CH3:13])[CH3:10]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a flask containing 4 gms 4-hydroxymethyl imidazole hydrochloride in 30 ml dimethylformamide add 3.1 ml vinylethyl ether and 50 mg paratoluene sulfonic acid. Stir for 11/2 hours until the reaction is complete. Extract from saturated K2CO3 /NaCl with ethylacetate to obtain 1-ethoxy-1-(imidazol-4-yl)methoxy ethane.
Aufarbeitung
- extractionExtract from saturated K2CO3 /NaCl with ethylacetate
Quellen und Nachweise
- ORD-Eintrag
- ord-66bf058a84f94f76b34dcf0fdc9167ee
- Quelldatensatz
- uspto-grants-1986_05
- Patentnummer
- US04587241
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