N-(3-bromophenyl)-3-oxobutanamide → HCID 178429223, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:14])[CH2:10][C:11](=O)[CH3:12])[CH:5]=[CH:6][CH:7]=1>S(=O)(=O)(O)O>[OH:14][C:9]1[CH:10]=[C:11]([CH3:12])[C:5]2[C:4](=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)[N:8]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
6.65 g (26.00 mM) of N-(3-bromophenyl)-3-oxobutyramide was heated in 30 mL of conc. sulfuric acid to 120° C. (oil bath temperature) for 1.5 h. The reaction mixture was then poured into ice, whereby precipitate was formed. This was filtered and washed repeatedly with water. After drying, it was recrystallised in 95% ethanol, providing 5.21 g (84%) of the product as a white solid: mp 275°-276° C.;
Aufarbeitung
- additionThe reaction mixture was then poured into ice
- customwhereby precipitate was formed
- filtrationThis was filtered
- washwashed repeatedly with water
- customAfter drying
- customit was recrystallised in 95% ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-a0b98b5ab3084f38a9a26fd3520d5c65
- Quelldatensatz
- uspto-grants-1986_05
- Patentnummer
- US04587341
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