Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate → Methyl 7,8-dimethoxy-2H-1-benzopyran-5-carboxylate

HRID 280022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 280022
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([O:15][CH2:16][C:17]#[CH:18])[C:12]=1[O:13][CH3:14])[C:6]([O:8][CH3:9])=[O:7]>C(N(CC)C1C=CC=CC=1)C.C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]2[O:15][CH2:16][CH:17]=[CH:18][C:10]2=[C:5]([C:6]([O:8][CH3:9])=[O:7])[CH:4]=1

Komponenten

4

Edukt 1

HCID 12849835Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate

Produkt 1

HCID 12849831Methyl 7,8-dimethoxy-2H-1-benzopyran-5-carboxylateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 7061N,N-DiethylanilineLösungsmittel

Versuchsvorschrift

Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate (390 g, 1.56 mol) in N,N-diethylaniline (0.4 L) was refluxed for 40 min. The solution was cooled and diluted with methylene chloride (2 L). The organic solution was extracted with 1N hydrochloric acid (5×1 L), dried (MgSO4) and concentrated to give title compound (390 g, 100%).

Aufarbeitung

  1. temperatureThe solution was cooled
  2. extractionThe organic solution was extracted with 1N hydrochloric acid (5×1 L)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a6af8e623b8d4dbfab279786ada31671
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04587342

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