Triethylamine → HCID 13478097, Verbindung

HRID 280096

Reaktionsgleichung

Reaktionsgleichung von HRID 280096
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:12][C:13]1[CH:28]=[CH:27][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1.C(N(CC)CC)C>C(O)(C)C>[F:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:2]3[N:11]=[CH:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[N:3]=3)[CH2:25][CH2:26]2)=[CH:27][CH:28]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 740542-ChloroquinazolineHCID 18733961-[3-(4-Fluorophenoxy)propyl]piperazine

Produkt 1

HCID 13478097HCID 13478097, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2.5 g 2-Chloro-quinazoline, 3.8 g 1-[3-(4-fluorophenoxy)propyl]piperazine and 2.5 ml triethylamine in 15 ml isopropanol are stirred under reflux for 5 hours. The solvent is then evaporated in vacuo and the residue partitioned between water and methylene chloride. The organic phase is dried and evaporated. The residue is recrystallized from ethanol to yield the title compound, m.p. 126°-128° C.

Aufarbeitung

  1. temperatureunder reflux for 5 hours
  2. customThe solvent is then evaporated in vacuo
  3. customthe residue partitioned between water and methylene chloride
  4. customThe organic phase is dried
  5. customevaporated
  6. customThe residue is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-87f2de8023f14f53ac1b7ff2295fa747
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04588725

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