Methyl iodide → 4-methoxy-2,3-dihydro-1H-inden-1-one

HRID 280152

Reaktionsgleichung

Reaktionsgleichung von HRID 280152
CI.[OH:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:13].[C:14](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:14][O:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:13]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 5905474-Hydroxy-1-indanone

Produkt 1

HCID 45474914-methoxy-2,3-dihydro-1H-inden-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Methyl iodide (69 ml) is added dropwise over a period of 15 minutes to a stirred mixture of 4-hydroxy-1-indanone (150 g) and anhydrous potassium carbonate (154 g) dissolved in DMF (1.5 liter) cooled to 0° C. under nitrogen. The reaction mixture is stirred at RT for 24 hours and partitioned between methylene chloride and water. The methylene chloride fraction is washed with water and 2% aqueous NaOH and dried over Na2SO4. The dried extract is filtered, concentrated in vacuo and the residue dissolved in hot methanol which upon cooling forms a precipitate. The precipitate is filtered and recrystallized from methanol yielding the methoxy product as a solid, M.P. 104°-106° C.

Aufarbeitung

  1. custompartitioned between methylene chloride and water
  2. washThe methylene chloride fraction is washed with water and 2% aqueous NaOH
  3. dry with materialdried over Na2SO4
  4. extractionThe dried extract
  5. filtrationis filtered
  6. concentrationconcentrated in vacuo
  7. dissolutionthe residue dissolved in hot methanol which
  8. temperatureupon cooling forms a precipitate
  9. filtrationThe precipitate is filtered
  10. customrecrystallized from methanol yielding the methoxy product as a solid, M.P. 104°-106° C.

Quellen und Nachweise

ORD-Eintrag
ord-0d932194cf3c4aefb55369fad0a4e158
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04588719

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