Phenylglyoxal → N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-phenyl ethanamine

HRID 280307

Reaktionsgleichung

Reaktionsgleichung von HRID 280307
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([CH3:13])([CH3:12])[NH2:11])=[CH:4][CH:3]=1.FC(F)(F)[C:16]1[CH:17]=[C:18]([C:22]([CH:24]=O)=[O:23])[CH:19]=[CH:20][CH:21]=1.C1(C(C=O)=O)C=CC=CC=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([NH:11][CH2:24][CH:22]([OH:23])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:16][CH:17]=2)([CH3:13])[CH3:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 14090PhenylglyoxalHCID 27832843-(Trifluoromethyl)phenylglyoxalHCID 233221672-Methyl-4-(4-methylphenyl)butan-2-amine

Produkt 1

HCID 23322158N-(3-(4-Methylphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-phenyl ethanamine

Versuchsvorschrift

The title compound was prepared in the manner described in Example 9, replacing 2-(4-methylphenyl)-1,1-dimethylethanamine by 3-(4-methylphenyl)-1,1-dimethylpropanamine and 3-trifluoromethylphenyl glyoxal by phenylglyoxal. The chromatographed material was recrystallised from hexane to give the title compound m.p. 107-110. τ (CDCl3) 8.95 (6H, s), 8.2-8.7 (2H, m), 7.8 (3H, s), 7.3-7.7 (4H, m), 5.7-6.5 (2H, m), 5.5 (1H, t, J=6 Hz), 2.9 (4H, s), 2.7 (4H, m).

Aufarbeitung

  1. customThe title compound was prepared in the manner
  2. customThe chromatographed material was recrystallised from hexane

Quellen und Nachweise

ORD-Eintrag
ord-250f6c9aa124474789d01ccb26ee94bd
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04588749

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