Phenylglyoxal → HCID 23322164, Verbindung

HRID 280318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 280318
[C:1]1([C:7]([CH:9]=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([CH3:22])[NH2:21]>>[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([NH:21][CH2:9][CH:7]([OH:8])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:22]

Komponenten

3

Edukt 2

HCID 14090PhenylglyoxalHCID 541870α,2,4-Trimethylbenzeneethanamine

Produkt 1

HCID 23322164HCID 23322164, Verbindung

Versuchsvorschrift

The title compound was prepared in the manner described in Example 9 using phenylglyoxal and 2-(2,4-dimethylphenyl)-1-methylethanamine. The residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform. Recrystallization of the resulting solid from hexane gave the title compound m.p. 91-92 as a 6:94 mixture of diastereoisomers. τ(CDCl3) 8.9 (3H, d, J=6 Hz), 7.7 (6H, s), 6.9-7.6 (5H, (m) +2H, disappears with D2O) 5.35 (1H, m), 3.05 (3H, s), 2.68 (5H, m).

Aufarbeitung

  1. customThe title compound was prepared in the manner
  2. customThe residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform
  3. customRecrystallization of the resulting solid from hexane

Quellen und Nachweise

ORD-Eintrag
ord-33c0f56da80248e6a6139b4be30369e5
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04588749

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