HCID 178419747, Verbindung → HCID 178419718, Verbindung

HRID 280743

Reaktionsgleichung

Reaktionsgleichung von HRID 280743
Br.[Br:2][CH2:3][C:4]([C:6]([C:8]1[N:9]=[CH:10][NH:11][CH:12]=1)=[O:7])=O.[C:13]([NH:16][C:17]([NH2:19])=[S:18])(=[NH:15])[NH2:14]>CC(C)=O>[BrH:2].[NH:16]([C:17]1[S:18][CH:3]=[C:4]([C:6]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[O:7])[N:19]=1)[C:13]([NH2:15])=[NH:14]

Komponenten

4

Edukt 2

HCID 178419747HCID 178419747, VerbindungHCID 178513045HCID 178513045, Verbindung

Produkt 1

HCID 178419718HCID 178419718, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 0.38 g (1.4 mmol) of 2-bromo-1-(4-imidazoyl)ethanone hydrobromide in 10 ml of acetone was warmed until homogeneous, then 0.17 g (1.4 mmol) of amidinothiourea was added and the mixture was heated at reflux for 0.5 hour. The mixture was cooled and the white precipitate was collected, washed with ether, and dried, thereby affording 0.24 g (60%) of 2-guanidino-4-(4-imidazoyl)thiazole hydrobromide, mp 225° (dec). nmr (DMSO-d6) (δ): 8.20 (s, 1H); 8.0 (b, 4H); 7.77 (s, 1H); 7.36 (s, 1H); high resolution mass spectrum: calcd. C7H8N6S: for 208.0531; found: 208.0517; calcd. for C7H8N6S.HBr.H2O: C, 27.37; H, 3.60; N, 27.36; found: C, 27.23; H, 3.57; N, 27.64.

Aufarbeitung

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureat reflux for 0.5 hour
  4. temperatureThe mixture was cooled
  5. customthe white precipitate was collected
  6. washwashed with ether
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-922d650cb64241289e428f4eb9116d5a
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04590299

Verknüpfte Notizen

Wird geladen…