3-Bromothiophene → 1-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)propanol

HRID 2813

Reaktionsgleichung

Reaktionsgleichung von HRID 2813
Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[CH3:7][C:8]1[O:9][C:10]([C:14](=[O:17])[CH2:15][CH3:16])=[C:11]([CH3:13])[N:12]=1>>[CH3:7][C:8]1[O:9][C:10]([C:14]([C:2]2[CH:6]=[CH:5][S:4][CH:3]=2)([OH:17])[CH2:15][CH3:16])=[C:11]([CH3:13])[N:12]=1

Komponenten

3

Edukt 2

HCID 133833-BromothiopheneHCID 189363232,4-Dimethyl-5-propionyloxazole

Produkt 1

HCID 189363681-(2,4-Dimethyl-5-oxazolyl)-1-(3-thienyl)propanol

Versuchsvorschrift

Starting with 3-bromothiophene and 2,4-dimethyl-5-propionyloxazole and following the general method of Example 4 the title compound was prepared. Purification by preparative HPLC gave a white solid. M.p. 81°-83° C.

Quellen und Nachweise

ORD-Eintrag
ord-8c46d271dc924094b2300f23ad9e41d8
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731335

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