Formaldehyde → 2-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

HRID 28254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 28254
[CH2:1]([CH:5]([C:14]#[N:15])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])[CH2:2][CH2:3][CH3:4].N1C=CC=CC=1.[CH2:22]=[O:23]>[OH-].C([NH+](CC)CC)C.C1C=CC=CC=1>[C:14]([C:5]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:22][OH:23])#[N:15]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 1049PyridineHCID 123432572-(2,4-Dichlorophenyl)hexane nitrile

Produkt 1

HCID 233399042-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23339897Benzene triethylammonium hydroxideLösungsmittel

Versuchsvorschrift

To an ice cold stirred solution of a-n-butyl-2,4-dichlorobenzyl cyanide (5g., 0.02 mole) in 20 ml. of pyridine containing a suspension of paraformaldehyde (2.4g., 0.08 mole) is added 1 ml. of benzene triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 16 hours. The reaction mixture is poured into 300 ml. of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 5.6g. of a thick oil, which is identified by nmr.

Aufarbeitung

  1. additionis added 1 ml
  2. additionThe reaction mixture is poured into 300 ml
  3. extractionof water and extracted with ether
  4. washThe combined ether extracts are washed with water, saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is evaporated
  7. customto give 5.6g

Quellen und Nachweise

ORD-Eintrag
ord-1a195b73c5554f77aaf4b1251b91003e
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04225723

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