Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine

HRID 2849

Reaktionsgleichung

Reaktionsgleichung von HRID 2849
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[O:6]=[C:2]([CH3:1])[CH2:3][C:4]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:5]

Komponenten

4

Edukt 2

HCID 31268PyrrolidineHCID 87118046Diketene acetone

Produkt 1

HCID 1007221-(1,3-Dioxobutyl)pyrrolidineAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

Aufarbeitung

  1. customas described in preparation 7
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

Quellen und Nachweise

ORD-Eintrag
ord-fc50405695d1443a80eda06a3dd99d45
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731322

Verknüpfte Notizen

Wird geladen…