Pyridine → 3-[2(r)-{Hydroxycarbonylpropyl-amino}-2-phenylethyl]-5-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-pyrimidine-2,4(1h,3h)-dione

HRID 28498

Reaktionsgleichung

Reaktionsgleichung von HRID 28498
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9](=[O:37])[N:10]([CH2:28][C@H:29]([NH2:36])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:11](=[O:27])[N:12]([CH2:15][C:16]2[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:17]=2[F:26])[C:13]=1[CH3:14].[CH2:38]([CH:43]=O)[CH2:39][C:40]([OH:42])=[O:41].N1C=CC=CC=1>CO>[OH:42][C:40]([CH2:39][CH2:38][CH2:43][NH:36][C@H:29]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:28][N:10]1[C:9](=[O:37])[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[C:13]([CH3:14])[N:12]([CH2:15][C:16]2[C:21]([C:22]([F:25])([F:23])[F:24])=[CH:20][CH:19]=[CH:18][C:17]=2[F:26])[C:11]1=[O:27])=[O:41]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 11124-Oxobutanoic acidHCID 210276755-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-3-[2(R)-amino-2-phenylethyl]-pyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 210276733-[2(r)-{Hydroxycarbonylpropyl-amino}-2-phenylethyl]-5-(2-chlorophenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-pyrimidine-2,4(1h,3h)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To compound 2b (0.03 mmol) in 1 mL MeOH, succinic semialdehyde (0.03 mmol) was added followed by addition of 8 M BH3:Pyridine (0.03 mmol). After overnight shaking, the compound 2-1 was purified by prep. LC-MS. MS (CI) m/z 618.2 (MH+) tR=1.005 (method 1)

Aufarbeitung

  1. additionfollowed by addition of 8 M
  2. customthe compound 2-1 was purified by prep

Quellen und Nachweise

ORD-Eintrag
ord-1684443c3aab4cceb83afc059f9728d8
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419983B2

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