Dimethylamine → Dimethylacetoacetamide

HRID 2851

Reaktionsgleichung

Reaktionsgleichung von HRID 2851
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 87118046Diketene acetone

Produkt 1

HCID 16278Dimethylacetoacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

Quellen und Nachweise

ORD-Eintrag
ord-eb592b1203c74e969732293b7513ee02
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731322

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