1H-Indazol-6-amine → [6-(5-Chloro-2-methyl-phenyl)-2-methyl-pyrimidin-4-yl]-(1H-indazol-6-yl)-amine

HRID 28562

Reaktionsgleichung

Reaktionsgleichung von HRID 28562
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[CH3:15])[N:5]=[C:4]([CH3:16])[N:3]=1.[NH2:17][C:18]1[CH:26]=[C:25]2[C:21]([CH:22]=[N:23][NH:24]2)=[CH:20][CH:19]=1>>[Cl:14][C:12]1[CH:11]=[CH:10][C:9]([CH3:15])=[C:8]([C:6]2[N:5]=[C:4]([CH3:16])[N:3]=[C:2]([NH:17][C:18]3[CH:26]=[C:25]4[C:21]([CH:22]=[N:23][NH:24]4)=[CH:20][CH:19]=3)[CH:7]=2)[CH:13]=1

Komponenten

3

Edukt 2

HCID 814231H-Indazol-6-amineHCID 860043234-Chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine

Produkt 1

HCID 11371530[6-(5-Chloro-2-methyl-phenyl)-2-methyl-pyrimidin-4-yl]-(1H-indazol-6-yl)-amineAusbeute 64 %

Versuchsvorschrift

Following the method described in Example 38 (alternate method), 4-chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine and 6-aminoindazol provided the title compound (64% yield). 1H NMR (DMSO-d6) δ 2.32 (s, 3H, CH3), 2.57 (s, 3H, CH3), 6.78 (s, 1H, Ar), 7.18 (dd, 1H, J=8.7 Hz, J=1.6 Hz, Ar), 7.36 (d, 1H, J=8.2 Hz, Ar), 7.43 (dd, 1H, J=8.2 Hz, J=2.3 Hz, Ar), 7.49 (d, 1H, J=2.2 Hz, Ar), 7.69 (d, 1H, J=8.6 Hz, Ar), 7.97 (s, 1H, Ar), 8.33 (s, 1H, Ar), 9.75 (s, 1H, NH), 12.89 (s, 1H, NH).

Quellen und Nachweise

ORD-Eintrag
ord-4da276ddc93446679d40ab6fbb578964
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419984B2

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