p-Toluidine → 6-[5-Bromo-2-(2-methoxy-benzyloxy)-phenyl]-N*4*-p-tolyl-pyrimidine-2,4-diamine

HRID 28662

Reaktionsgleichung

Reaktionsgleichung von HRID 28662
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])=[C:6]([C:8]2(Cl)[NH:13][C:12]([NH2:14])=[N:11][CH:10]=[CH:9]2)[CH:7]=1.[CH3:26][C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])=[C:6]([C:8]2[N:13]=[C:12]([NH2:14])[N:11]=[C:10]([NH:33][C:30]3[CH:31]=[CH:32][C:27]([CH3:26])=[CH:28][CH:29]=3)[CH:9]=2)[CH:7]=1

Komponenten

3

Edukt 2

HCID 7813p-ToluidineHCID 178489517HCID 178489517, Verbindung

Produkt 1

HCID 426069906-[5-Bromo-2-(2-methoxy-benzyloxy)-phenyl]-N*4*-p-tolyl-pyrimidine-2,4-diamineAusbeute 36 %

Versuchsvorschrift

Following the method described in Example 4, 6-[5-bromo-2-(2-methoxy-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine and 4-methyl-phenylamine provided the title compound (36% yield). 1H NMR (CD3OD) δ 3.82 (s, 3H, CH3), 5.25 (s, 2H, CH2), 6.32 (s, 1H, Ar), 6.89-6.98 (m, 2H, Ar), 7.21-7.30 (m, 6H, Ar), 7.59-7.72 (m, 3H, Ar).

Quellen und Nachweise

ORD-Eintrag
ord-f7275f0f88e743ceab141c46b63b009a
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419984B2

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