Sulfuric Acid → Methyl 1-phenylcyclopentane-1-carboxylate

HRID 28776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 28776
C[CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1F)[C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[C:22](=O)([O-])[O-].[Na+].[Na+]>CO>[C:10]1([C:3]2([C:7]([O:9][CH3:22])=[O:8])[CH2:4][CH2:5][CH2:6][CH2:2]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 69250408Methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid

Produkt 1

HCID 11790325Methyl 1-phenylcyclopentane-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid (10 g, 52.56 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

Aufarbeitung

  1. temperatureThe mixture was refluxed for overnight
  2. customThe solvent was evaporated
  3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
  4. washwashed with brine (3×10 mL)
  5. dry with materialdried over MgSO4
  6. customThe crude product was used for the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a71a3a42cc19407fb7c47e676264a086
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419999B2

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