Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile

HRID 2888

Reaktionsgleichung

Reaktionsgleichung von HRID 2888
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1

Komponenten

4

Edukt 2

HCID 9032Potassium CyanideHCID 153368673-(7-Methoxy-1-naphthyl)propyl mesylate

Produkt 1

HCID 153368684-(7-Methoxy-1-naphthyl)butyronitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

Aufarbeitung

  1. temperatureto reflux for 2 h
  2. temperatureto cool
  3. extractionThe resulting mixture is extracted with ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over CaCl2
  6. customevaporated
  7. customThe product obtained
  8. customis recrystallized

Quellen und Nachweise

ORD-Eintrag
ord-ebf01e6b38bc42c089b9940d05b2423f
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731352

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