Sodium Hydroxide → Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

HRID 29445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 29445
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[Cl:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 63357893Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate

Produkt 1

HCID 68717138Sodium 5-chloro-1,3-benzothiazole-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 5-chloro-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.83 mmol) was added 3 mL of THF, and 0.83 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 170 mg of 5-chloro-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

Aufarbeitung

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fc3d1e80ce71433185d60e5556f9662d
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07420001B2

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