(1,1'-Biphenyl)-4-sulphonyl chloride → Biphenyl4-sulfonic acid [4-chloro-2-(pyridine-4-carbonyl)-phenyl]-amide

HRID 29559

Reaktionsgleichung

Reaktionsgleichung von HRID 29559
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)=[O:10].[C:17]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][S:23]([C:20]2[CH:19]=[CH:18][C:17]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:22][CH:21]=2)(=[O:25])=[O:24])=[C:3]([C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])[CH:4]=1

Komponenten

3

Edukt 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 10214538(2-Amino-5-chlorophenyl)-pyridin-4-yl methanone

Produkt 1

HCID 10049353Biphenyl4-sulfonic acid [4-chloro-2-(pyridine-4-carbonyl)-phenyl]-amide

Versuchsvorschrift

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 126 mg of biphenyl-4-sulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 7.24 (m, 1H), 7.36 (m, 2H), 7.42 (m, 5H), 7.56 (m, 3H), 7.77-7.84 (m, 3H), 8.73 (d, 2H, J=4.4 Hz), 10.01 (s,1H). MS: m/z 449.0 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-e2ab564166e7485085282928fae95fc6
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07420055B2

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