4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)phenyl]-4-oxazol-5-yl-benzenesulfonamide

HRID 29566

Reaktionsgleichung

Reaktionsgleichung von HRID 29566
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=1)=[O:10].[O:18]1[C:22]([C:23]2[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=2)=[CH:21][N:20]=[CH:19]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][S:29]([C:26]2[CH:27]=[CH:28][C:23]([C:22]3[O:18][CH:19]=[N:20][CH:21]=3)=[CH:24][CH:25]=2)(=[O:30])=[O:31])=[C:3]([C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[CH:12]=2)=[O:10])[CH:4]=1

Komponenten

3

Edukt 2

HCID 27764154-(1,3-Oxazol-5-yl)benzenesulphonyl chlorideHCID 22327293(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone

Produkt 1

HCID 10321702N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)phenyl]-4-oxazol-5-yl-benzenesulfonamide

Versuchsvorschrift

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 123 mg of (2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone and 122 mg of 4-oxazol-5-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 2.78 (s, 3H), 7.29 (d,1H, J=2.8 Hz), 7.45 (m, 2H), 7.48 (s,1H), 7.55 (dd,1H, J=9.2 Hz, 2.8 Hz)), 7.67 (m, 3H), 7.83 (d, 2H, J=8.4 Hz), 8.03 (s,1H), 8.81 (d, 1H, J=5.6 Hz), 10.10 (s, 1H). MS: m/z454.9 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-c43d67a0d52e4ebf8b7993002a49b695
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07420055B2

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