Reaktionsgleichung
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[N:12][O:13][CH2:14][CH2:15][O:16][C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[C:19]([OH:26])[CH:18]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:27][C:28]([F:38])([F:37])[C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[N:12][O:13][CH2:14][CH2:15][O:16][C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[C:19]([O:26][CH2:33][C:32]3[CH:31]=[CH:30][C:29]([C:28]([F:27])([F:37])[F:38])=[CH:36][CH:35]=3)[CH:18]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
The title compound was prepared as a white solid from 4-{2-[({[4-(tert-butyl)phenyl]methylidene}amino)oxy]-ethoxy}-2-hydroxybenzoic acid and 4-trifluromethyl benzyl bromide using a procedure similar to that of step 1 of example 6 followed by a procedure similar to that of step 3 of example 1. mp=164.1-164.8° C.; mass spectrum (+APCI, M+H) m/z 516. 1H NMR (400 MHz, DMSO-d6); δ 12.30 (s, 1H), 8.24 (s, 1H), 7.72 (m, 5H), 7.53 (d, 2H), 7.42 (d, 2H), 6.75 (d, 1H), 6.63 (dd, 1H), 5.29 (s, 2H), 4.41 (t, 2H), 4.3 (t, 2H), 1.25 (s, 9H). Elemental analysis: Calcd. for C28H28F3NO5: C, 65.24; H, 5.47; N, 2.72, Found: C, 63.30; H, 5.21; N, 2.68.
Quellen und Nachweise
- ORD-Eintrag
- ord-ece64afed3624682bd1e2fcf118a7e54
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07420083B2
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