Phenylacetic Acid → 8-Benzyl-3-[2-(3-carboxyphenyl)ethyl]-1-propylxanthine
Reaktionsgleichung
[C:1]1([CH2:7][C:8](O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[C:13](=[O:34])[N:14]([CH2:31][CH2:32][CH3:33])[C:15](=[O:30])[N:16]([CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([OH:29])=[O:28])[CH:22]=2)[C:17]=1[NH2:18]>>[CH2:7]([C:8]1[NH:11][C:12]2[C:13](=[O:34])[N:14]([CH2:31][CH2:32][CH3:33])[C:15](=[O:30])[N:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([OH:29])=[O:28])[CH:22]=3)[C:17]=2[N:18]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Komponenten
3
Versuchsvorschrift
By the method of Example 2, phenylacetic acid is reacted with 5,6-diamino-1-[2-(3-carboxyphenyl)ethyl]-3-propyluracil to yield 8-benzyl-3-[2-(3-carboxyphenyl)ethyl]-1-propylxanthine. In turn, 5,6-diamino-1-[2-(3-carboxyphenyl)ethyl]-3-propyluracil is made by the synthetic methods of Example 1, starting with 3-carboxyphenethylamine.
Quellen und Nachweise
- ORD-Eintrag
- ord-869ecfbdc8334f0b994f426f36fc0aef
- Quelldatensatz
- uspto-grants-2008_09