Phosphorus oxychloride → 1-Chloro-4-cyclopentyl-7-methoxyphthalazine

Reaktionsgleichung

[CH:1]1([C:6]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9](=O)[NH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[C:6]([CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:7][N:8]=1

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 692139674-cyclopentyl-7-methoxy-2H-phthalazin-1-one

Produkt 1

HCID 866122231-Chloro-4-cyclopentyl-7-methoxyphthalazine

Versuchsvorschrift

This compound is obtained according to the procedure described in 1.3. by reacting 4-cyclopentyl-7-methoxy-2H-phthalazin-1-one with phosphoryl chloride. The product is too impure for a description by NMR. It is used as obtained in the following amination reaction.

Aufarbeitung

customThis compound is obtained
customas obtained in the
customfollowing amination reaction

Quellen und Nachweise

ORD-Eintrag: ord-98b16decaa6b48368c3a5825c80b03eb
Quelldatensatz: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07423030B2

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