HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 30044Erstellt: 23. Oktober 2026
Sodium Hydroxide → 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine
https://huagongshe.com/de/reaction/30044
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine | HCID 11554683 | — |
| Edukt | Pyridinium hydrochloride | HCID 21584435 | — |
| Produkt | 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine | HCID 136394903 | 86,8% |
Reaktionsschritte
A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07423030B2 |
|---|
| Quelldatensatz | uspto-grants-2008_09 |
|---|
| ORD ID | ord-e9b7e2235a7a47bfab84ebdfc02c564b |
|---|
| Quellennotiz | uspto-grants-2008_09 |
|---|
