HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Propanesulfonyl chloride → {2-Amino-6-[1-(propane-1-sulfonyl)-piperidin-4-ylamino]-pyridin-3-yl}-(5-fluoro-2-methoxy-phenyl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Propanesulfonyl chloride | HCID 66279 | — |
| Edukt | [4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 21070627 | — |
| Produkt | {2-Amino-6-[1-(propane-1-sulfonyl)-piperidin-4-ylamino]-pyridin-3-yl}-(5-fluoro-2-methoxy-phenyl)-methanone | HCID 11612128 | — |
Reaktionsschritte
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and 1-propanesulfonyl chloride (Aldrich 97%) using the procedure described in Example 24. HRMS, observed 451.1817, Calcd for (M+H)+: 451.1810.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07423051B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-51a5a36a1d9d4394894e28c02dcdbd7b |
| Quellennotiz | uspto-grants-2008_09 |