Methyl chloroformate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methyl chloroformate	HCID 6586	—
Edukt	[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt	HCID 21070627	—
Produkt	4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methyl ester	HCID 11682804	—

Reaktionsschritte

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and methylchloroformate (Aldrich 99%) using the procedure described in Example 24. HRMS, observed: 403.1781, Calcd for (M+H)+: 403.1776.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07423051B2
Quelldatensatz	uspto-grants-2008_09
ORD ID	ord-31a61cf1ce0740a79d0ce110afcd2bff
Quellennotiz	uspto-grants-2008_09