Ethyl 4-amino-1-piperidinecarboxylate → 4-[6-Amino-5-(2,3-difluoro-6-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester

HRID 30138

Reaktionsgleichung

Reaktionsgleichung von HRID 30138
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[CH2:21]([O:23][C:24]([N:26]1[CH2:31][CH2:30][CH:29]([NH2:32])[CH2:28][CH2:27]1)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24]([N:26]1[CH2:27][CH2:28][CH:29]([NH:32][C:4]2[CH:5]=[CH:6][C:7]([C:8](=[O:9])[C:10]3[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=3[F:19])=[C:2]([NH2:1])[N:3]=2)[CH2:30][CH2:31]1)=[O:25])[CH3:22]

Komponenten

3

Edukt 2

HCID 100867Ethyl 4-amino-1-piperidinecarboxylateHCID 58590826(2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone

Produkt 1

HCID 116189234-[6-Amino-5-(2,3-difluoro-6-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester

Versuchsvorschrift

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 39) and ethyl4-amino-1-piperidine carboxylate (Aldrich 96%) using the procedure described in Step B. Example 6. HRMS, observed: 435.1841, Calcd for (M+H)+: 435.1839.

Quellen und Nachweise

ORD-Eintrag
ord-5c3315121bdc4bc1aad92080981404d0
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423051B2

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