1-(4-Aminopiperidin-1-yl)ethan-1-one → 1-{4-[6-Amino-5-(2,3-difluoro-6-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH2:21][CH:22]1[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]1>>[NH2:1][C:2]1[N:3]=[C:4]([NH:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:9])[C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=1[F:19]Komponenten
3
Versuchsvorschrift
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 39) and 1-(4-amino-piperidin-1-yl)-ethanone (prepared as described in Manetti et al, Biorg. Med. Chem. Lett., 13 (2003), 2303-2306) using the procedure described in Step B. Example 6. HRMS, observed: 405.1734, Calcd for (M+H)+: 405.1733.
Quellen und Nachweise
- ORD-Eintrag
- ord-d0d874125cba4881921bbd6d93a6e292
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07423051B2
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