1-(4-Aminopiperidin-1-yl)ethan-1-one → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone

HRID 30141

Reaktionsgleichung

Reaktionsgleichung von HRID 30141
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH2:21][CH:22]1[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]1>>[NH2:1][C:2]1[N:3]=[C:4]([NH:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28](=[O:30])[CH3:29])[CH2:24][CH2:23]2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:9])[C:10]1[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=1[O:18][CH3:19]

Komponenten

3

Edukt 2

HCID 49624771-(4-Aminopiperidin-1-yl)ethan-1-oneHCID 58590831(2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone

Produkt 1

HCID 585908341-{4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone

Versuchsvorschrift

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and 1-(4-amino-piperidin-1-yl)-ethanone (prepared as described in D. Manefti et al, Biorg. Med. Chem. Lett., 13 (2003), 2303-2306) using the procedure described in Step B. Example 6. HRMS, observed: 401.1084, Calcd for (M+H)+: 401.1084.

Quellen und Nachweise

ORD-Eintrag
ord-dc408dbe1e004e01b4e7c5f362a58f9d
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423051B2

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