Pyridine, hydrofluoride (1:1) → methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Pyridine, hydrofluoride (1:1)	HCID 64774	—
Edukt	methyl (11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoate	HCID 22883791	—
Produkt	methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate	HCID 22883792	28%

Reaktionsschritte

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.7 ml) and methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoate (734 mg), the same procedure as in Example 2 was performed to obtain methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate (141 mg, 28%)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05731452
Quelldatensatz	uspto-grants-1998_03
ORD ID	ord-22a46d06c9484f61abcb3ba9fcd4507b
Quellennotiz	uspto-grants-1998_03