HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diethyl Malonate → HCID 178418389, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diethyl Malonate | HCID 7761 | — |
| Edukt | Acetamidine monohydrochloride | HCID 67170 | — |
| Edukt | Sodium ethoxide | HCID 2723922 | — |
| Edukt | Sodium | HCID 5360545 | — |
| Edukt | 4,6-Dihydroxy-2-methylpyrimidinamine | HCID 178418345 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | HCID 178418389 | HCID 178418389 | — |
Reaktionsschritte
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05732717 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-4d14267579d347aaab5da8765031fa8d |
| Quellennotiz | uspto-grants-1998_03 |