HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N,N,N',N',N'',N''-Hexamethylmethanetriamine | HCID 79831 | — |
| Edukt | 2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester | HCID 11088396 | — |
| Edukt | (S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11687992 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11523197 | — |
Reaktionsschritte
According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07423152B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-bbd7d798654d40d2a16d1a5d7de0ddf3 |
| Quellennotiz | uspto-grants-2008_09 |