Tetrahydrofuran → Methyl 4-hydroxy-2-methoxybenzoate

HRID 30740

Reaktionsgleichung

Reaktionsgleichung von HRID 30740
C([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1)C1C=CC=CC=1.O1CCCC1>CO.[C].[Pd]>[OH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 108260394-Benzyloxy-2-methoxybenzoic acid methyl ester

Produkt 1

HCID 12532676Methyl 4-hydroxy-2-methoxybenzoateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 4-benzyloxy-2-methoxybenzoate (3.08 g) in methanol (5 mL)/tetrahydrofuran (7.5 mL) was added 10% palladium-carbon (0.3 g) at room temperature under an atmosphere of argon, and the mixture was stirred at that temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to afford the title compound (2.02 g).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cac98ee240c347b09e50e6d4c18e0653
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423185B2

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