2,2,3,3,3-Pentafluoropropylamine → N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide

HRID 31011

Reaktionsgleichung

Reaktionsgleichung von HRID 31011
[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:17](=[O:18])[C@@H:16]([NH:19][C:20](=[O:28])[CH:21]([O:25][CH2:26][CH3:27])[C:22]([OH:24])=O)[C:15]2[CH:29]=[CH:30][CH:31]=[CH:32][C:14]=2[C:13]2[CH:33]=[CH:34][CH:35]=[CH:36][C:12]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:37][C:38]([F:45])([C:41]([F:44])([F:43])[F:42])[CH2:39][NH2:40]>>[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:17](=[O:18])[C@@H:16]([NH:19][C:20](=[O:28])[CH:21]([O:25][CH2:26][CH3:27])[C:22]([NH:40][CH2:39][C:38]([F:45])([F:37])[C:41]([F:44])([F:43])[F:42])=[O:24])[C:15]2[CH:29]=[CH:30][CH:31]=[CH:32][C:14]=2[C:13]2[CH:33]=[CH:34][CH:35]=[CH:36][C:12]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 58972534HCID 58972534, Verbindung

Produkt 1

HCID 58972527N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide

Versuchsvorschrift

Using N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-malonamic acid and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 1c. White solid. (82%). MS: m/e=620(M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-cb22431ba06149feb37a73cd0e961253
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425551B2

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