HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloro-5-(trifluoromethyl)pyridine → 2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| Edukt | 2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)-5-nitropyridine | HCID 17978501 | — |
| Edukt | 2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-ol | HCID 17978573 | — |
| Produkt | 2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine | HCID 17978517 | — |
Reaktionsschritte
2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine was prepared in the same way as 2-(2,3-dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)-5-nitropyridine above from 2,3-dihydro-2-phenyl-benzo[1,4]dioxin-6-ol (80 mg) and 2-chloro-5-(trifluoromethyl)pyridine (64 mg). Yield is 50 mg and mp 104-110° C. 1H NMR (DMSO-d6) δ=4.15 (dd, J=8.3, 11.4Hz, 1H), 4.46 (dd, J=2.3, 11.4 Hz, 1H), 5.27 (dd, J=2.3, 8.3 Hz, 1H), 6.72 (dd, J=2.8, 8.8 Hz, 1H), 6.84 (d, J=2.8 Hz, 1H), 7.03 (d, J=8.8 Hz, 1H), 7.19 (d, J=8.8 Hz, 1H), 7.39-7.52 (m, 5H), 8.20 (dd, J=8.8, 2.6 Hz, 1H), 8.58 (d, J=2.6 Hz, 1H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07425568B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-e03c632522f941e9ae797a26c3ce7c77 |
| Quellennotiz | uspto-grants-2008_09 |